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Updated: Sep 10, 2025

Quantifying Replication Stress in Ovarian Cancer Cells Using Single-Stranded DNA Immunofluorescence
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複製に関連したメカニズムは,不一致修復欠陥がんにおけるCpG > TpG変異負荷の増加に寄与する

Joseph C Ward1, Ignacio Soriano1, Steve Thorn1

  • 1Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.

Genome medicine
|August 25, 2025
PubMed
まとめ

不一致修復欠陥がんでは,不一致検出 (dMutSα) が CpG> TpG変異の増加を示しています. これらの変異はDNA複製の誤りによるもので,5メチルサイトシン脱アミネーションによるものではありません.

キーワード:
大腸がんDNA 修復不一致修復の欠陥についてミュタゲネシス変異シグネチャー

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