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Updated: Sep 10, 2025

Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro
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CHIPは,CLN4変異体による膜損傷からリソソームを保護する

Juhyung Lee1, Natalie Chin1, Jizhong Zou2

  • 1Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

Nature cell biology
|August 26, 2025
PubMed
まとめ

科学者はCHIP媒介のマイクロオートファギーは 細胞をリソソーム損傷から保護することを発見しました この経路は,ユビキチン・リガゼCHIPを伴うもので,細胞死とリポフューシン蓄積を減少させ,CLN4のような神経変性疾患に対する潜在的な治療戦略を提供します.

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