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Updated: Sep 10, 2025

Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
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グラス変換温度よりはるかに低い温度でのアモルフなテルフェナジンの核化とその物理的安定性への影響

Katsutoshi Yamaguchi1, Yuya Ishizuka2, Etsushi Yoshikawa2

  • 1Pharmaceutical Developability, CMC Research, Astellas Pharma Inc., 21Miyukigaoka, Tsukuba, Tsukuba, Ibaraki 3058585, Japan.

Molecular pharmaceutics
|August 26, 2025
PubMed
まとめ

アモルフなテルフェナジン (TFD) の調査は,−20 °Cでの熱熱が冷結晶化温度を大幅に低下させ,II形態の核形成を促進することを明らかにした. このプレアニリングステップは,より高い温度で後の結晶化を加速します.

キーワード:
形のない水晶の成長局所的な分子移動中核化物理的な安定性

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