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関連する概念動画

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
124
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

289
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
289
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
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Nightmares and Night Terrors01:18

Nightmares and Night Terrors

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Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
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関連する実験動画

Updated: Sep 10, 2025

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
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Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

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[循環器リズム障害と神経発達障害]

Deng-Feng Liu1, Yi-Chun Zhang1, Jia-Da Li1

  • 1Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078, China.

Sheng li xue bao : [Acta physiologica Sinica]
|August 26, 2025
PubMed
まとめ

循環器リズム障害や時計遺伝子の変異は 自閉症やADHDのような神経発達障害 (NDD) に寄与し 認知や感情の健康に影響します サーカディアン・システムをターゲットにすることで これらの疾患の新たな治療が 可能になります

科学分野:

  • 神経科学
  • 遺伝学
  • 睡眠医学

背景:

  • 自閉症スペクトル障害 (ASD),注意欠陥多動性障害 (ADHD),知的発達障害 (IDD) を含む神経発達障害 (NDD) は一般的であり,効果的な治療法がありません.
  • 睡眠障害はNDDで頻繁に観察され,疾患の重度と治療への反応と相関しています.
  • 新興の証拠は,昼間のリズム障害と昼間の時計遺伝子の変異をNDDの病原性と関連付けています.

研究 の 目的:

  • NDDにおける認知,行動,感情の欠陥と昼間のリズム障害と時計遺伝子変異を結びつけるメカニズムをレビューする.
  • NDDに関連する症状における ドーパミンのシステム不調の役割を調査する.
  • NDDの治療に生体循環系を標的とした治療の可能性について議論する.

主な方法:

  • サーカディアンリズム,時計遺伝子,神経発達障害に関する研究の文献レビュー.
  • シルカディアン不調とドーパミン経路の相互作用に焦点を当てた研究の分析
  • サーカディアンシステムを標的とした治療戦略に関する証拠の合成.

主要な成果:

  • NDDの病理生理学には,日経リズム障害と時計遺伝子変異が関与しています.
  • これらの障害はドーパミンシステムの調節障害を引き起こし,NDDの症状に寄与します.

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関連する実験動画

Last Updated: Sep 10, 2025

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex
12:06

Transmission Electron Microscopy as the Visualization Technique for Analysis of Circadian Synaptic Plasticity in the Mouse Barrel Cortex

Published on: August 19, 2025

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Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
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Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

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EEG Mu Rhythm in Typical and Atypical Development
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EEG Mu Rhythm in Typical and Atypical Development

Published on: April 9, 2014

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  • サーカディアンシステムは 新しい治療介入の有望なターゲットです

    • 結論:

    • NDDの発症と発現の重要な要因である.
    • これらのメカニズム,特にドーパミンシステムの関与を理解することは,治療開発にとって極めて重要です.
    • サーカディアン・システムをターゲットに NDDの治療に 新しく効果的なアプローチを提案しています