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Updated: Sep 10, 2025

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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3つの新しいアレル,HLA-DRB1*01:159,HLA-DRB1*04:402,HLA-DRB1*15:240,次世代配列決定により特定された

Maria Loginova1,2, Olga Makhova1, Igor Paramonov1

  • 1Federal State-Financed Scientific Institution: Kirov Research Institute of Hematology and Blood Transfusion Under the Federal Medical Biological Agency, Kirov, Russia.

HLA
|August 26, 2025
PubMed
まとめ

3つの新しいヒト白血球抗原 (HLA) -DRB1アレルは,次世代配列決定を用いて発見されました. これらの発見は,移植と疾患関連の研究にとって重要な既知のHLA-DRB1遺伝的変異を拡大します.

キーワード:
HLA-DRB1についてNGS について新型アレル

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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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