腸内微生物群は,中国人の成人における食用動物性タンパク質の摂取と骨のミネラル密度の間の曲線的関連を媒介した
Yan-Jun Deng1, Qiong Zhang1, Mao-Xin Ren1
1Department of Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China. xiaosm3@mail.sysu.edu.cn.
Food & function
|August 26, 2025
まとめ
動物性タンパク質の摂取は,骨のミネラル密度 (BMD) に最適なレベルであり,過剰な量は有害である可能性があります. 腸内微生物は タンパク質の摂取が骨の健康に 影響を及ぼし 骨粗鬆症の予防に 複雑な関係があることを示唆しています
科学分野:
- 栄養学
- 微生物群の研究
- 骨の健康 研究
背景:
- タンパク質の摂取は骨の健康と関連しているが,異なるタンパク質源と腸内微生物群の役割は不明である.
- これらの関係を理解することは,骨のミネラル密度 (BMD) を維持する戦略の開発に不可欠です.
研究 の 目的:
- 食事による動物性および植物性タンパク質の摂取とBMDとの関連を調査する.
- これらの関連性における腸内微生物の媒介的な役割を調べる.
主な方法:
- 1012人の参加者 (年齢18~64歳) を募集し,食事の頻度に関するアンケートで食事中のタンパク質摂取量を評価した.
- 二重エネルギーX線吸収計を用いてBMDを測定し,16S rRNA配列を用いて腸内微生物の組成を分析した.
主要な成果:
- 食事による動物性タンパク質の摂取は,骨髄量との反転したU型関係を示し,0. 87g/kg/日以下では肯定的な関連が見られ,この値を超えると減少傾向が見られた.
- 食事による植物性タンパク質の摂取は,腰椎と全腰椎のBMDと逆相関していた.
- 特定の腸内細菌系 (例えば,ラクトコッカス,ラクトニファクター) は,動物性タンパク質の摂取とBMDの関係を媒介した.
結論:
- BMDに対する食事中の動物性タンパク質の値効果は,部分的に腸内微生物によって媒介されます.
- 動物性タンパク質と 植物性タンパク質の過剰摂取は 骨の健康に良い影響を与えないかもしれません
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