非医療用窒素酸化物の若い使用者における精神的および神経認知的有害事象
Margot Lestienne1, Alexandra Macgregor2, Laurie Surig3
1Department of Medical Pharmacology and Toxicology, Addictovigilance Center.
Journal of clinical psychopharmacology
|August 26, 2025
まとめ
窒素酸化物 (N2O) の非医学的な使用は,若い成人の重度の神経精神疾患に関連しています. 未知の精神疾患や認知障害の診断には N2Oの乱用を早期に検討することが重要です
科学分野:
- 神経科学
- 精神科
- 毒理学について
背景:
- フランスの青少年と若者の間で非医療用酸化窒素 (N2O) の使用が増加している.
- N2Oの使用と重度の有害事象との間の関連性
研究 の 目的:
- N2O使用者における神経精神学的有害事象の自発的な報告を分析する.
- これらの現象の潜在的薬理学的メカニズムについて議論してください.
主な方法:
- モンペリエ中毒者警戒センター (2022年~2024年6月) の19件の重度の自発報告 (SR) の分析
- 患者の人口統計,報告された症状,関連する薬物使用,および生化学マーカー (ビタミンB12,ホモシステイン,メチルマロン酸,ビタミンB9) の評価
- 神経イメージング (MRI) の発見と治療介入のレビュー
主要な成果:
- 精神疾患,神経認知障害,または併合障害を持つ若い男性を対象とした報告が多かった.
- 行動障害や妄想障害,記憶障害,混乱といった症状がよく見られる.
- バイオケミカル異常 (ビタミンB12の低下,ホモシステイン/メチルマロン酸の上昇) と白質異常はMRIで頻繁に見られました.
- N2Oは,精神活性,生化学的 (ビタミンB12代謝障害),および無毒的メカニズムを通じて神経毒性を示します.
結論:
- N2Oが誘発する神経精神疾患は顕著で,はっきりしています.
- 未解明の精神疾患,特に非典型的認知症状を有する若い患者では,N2O乱用が疑われるべきである.
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