血圧と認知症における全因死亡率:全国的なコホート研究
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PubMedで要約を見る
まとめ
この要約は機械生成です。認知症患者の高血圧 (BP) は,死亡率とU型で関連しています. 低血圧と高血圧の両方が 認知症で死亡するリスクを高めます
科学分野
- ゲロントロジー
- 神経科学
- 心臓病科
背景
- 高血圧の管理は不可欠ですが,認知症患者への影響に関するデータは限られています.
- この研究では,認知症と診断された個人の血圧 (BP) と全死亡率との関係を調査しています.
研究 の 目的
- シストリック血圧 (SBP) とダイアストリック血圧 (DBP) と,多くの認知症患者の全因死亡率との関連を調査する.
- この集団における死亡リスクの増加に関連する特定の血圧の範囲を特定する.
主な方法
- 2008年から2016年の間に新たに認知症と診断された 146,832人の分析です
- 参加者はSBPとDBPレベルによって分類され,多変量Cox比危険性回帰を用いて全因死亡率が評価された.
- 認知症の診断は,抗認知症薬の処方箋とICD-10コードによって確認されました.
主要な成果
- SBPと死亡率との間には逆のJ型関連が認められ,最も低いリスクは138mmHgでした.
- 死亡リスクは,SBP < 100 mmHg とSBP ≥ 160 mmHg で,SBP 120 - 129 mmHg と比較して有意に増加しました.
- DBP ≥90 mmHgの死亡リスクは,DBP 70-79 mmHgと比較して線形的に増加しました.
結論
- 認知症の個人は,SBPと全因死亡率の間の逆のJ型関連性を示しています.
- ≥90 mmHgから始まる高血圧は,認知症患者の死亡リスクの増加と関連しています.
- これらの発見は,高齢者や抗高血圧薬を服用している患者を含む認知症サブタイプと患者サブグループに一致しました.
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