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Updated: Sep 10, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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PARP1の活性化に関する分子洞察:DNA,NAD+,および亜鉛媒介のアロステリック調節の構造動態

Areeba Munir1, Noorulain Naseer1, Taskeen Koser1

  • 1National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.

Journal of biomolecular structure & dynamics
|August 26, 2025
PubMed
まとめ

ポリ (ADP-リボース) ポリメラーゼ1 (PARP1) の活性化には,PARP1,DNA,亜鉛イオン,およびNAD+の複合体が必要です. この理解は 致死性の合成を 標的とするがん治療法を 開発するのに役立ちます

キーワード:
DNAダメージ認識PARP1の活性化アロステリック調節分子ダイナミクスシミュレーション癌における合成致死性

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