関連する実験動画

Updated: Sep 10, 2025

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
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オリゴ-1,6-グルコシダースの構造分析と分子工学

Jinshu Zhang1,2, Haocun Kong2, Yixiong Tian3,1

  • 1School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Journal of agricultural and food chemistry
|August 26, 2025
PubMed
まとめ

研究者はオリゴ-1,6-グルコシダースを設計して,製品阻害を克服し,グルコース生成の効率を高めました. トリプルミュータントは高血糖濃度で酵素活性と安定性を有意に改善しました.

キーワード:
クリスタル構造分子ダイナミクスシミュレーションオリゴ-1,6-グルコシダゼ製品阻害合理的なデザイン

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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
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Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
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