関連する実験動画

Updated: Sep 10, 2025

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
11:38

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

Published on: September 14, 2021

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TGF-β インデペンデントのSMAD4-NFATc1-STAT3 規制軸の識別と特徴付け

Wukun Ouyang1, Jiaying Hao1, Qiankun Niu1

  • 1Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Journal of molecular cell biology
|August 26, 2025
PubMed
まとめ

SMAD4タンパク質は,TGF-βシグナル伝達とは独立して細胞プロセスを調節する. 臓がん細胞におけるNFATc1との新しい相互作用により,SMAD4欠乏性腫瘍に対する新しい治療標的であるSTAT3が明らかになりました.

キーワード:
NFATc1 についてOncoPPI についてSMAD4 についてSTAT3 についてタンパク質とタンパク質の相互作用

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