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Updated: Sep 10, 2025

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
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In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

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PERK-p38 MAPK軸は,Fuchs内皮角膜縮症における内プラズマ網膜ストレス誘発性アポトーシスを誘発する

Takako Onishi1, Taichi Yuasa1, Naoyuki Ueda1

  • 1Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.

Investigative ophthalmology & visual science
|August 26, 2025
PubMed
まとめ

p38 MAPKは,エンドプラズマ網膜 (ER) ストレスによるフックス内皮角膜縮症 (FECD) の細胞死の主な媒介である. P38 MAPKを阻害すると,細胞死亡を減少させることで,FECDの治療の可能性を示します.

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