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便秘に対するセノシドとマグネシウム水酸化物とポリエチレングリコールとの比較:ランダム化クロスオーバー試験

Butsarin Nate-Anong¹, Jiraporn Khorana^1,2,3,4, Sireekarn Chantakhow^1,2

¹Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Pediatric surgery international

|August 26, 2025

まとめ

この研究では,Sennosides,マグネシウム水酸化物,またはポリエチレングリコールによるARM患者における便秘の治療における有効性または使用者の好みの有意な差異は認められなかった. 3つの放剤は,糞便のクリアランスと患者の満足度で比較可能な結果を示した.

科学分野:

胃腸内科
薬理学について
臨床医学

背景:

便秘は直腸不全 (ARM) の患者でよく見られる問題です.
便秘の効果的な管理は,ARM患者の生活の質を改善するために不可欠です.
セノシド,マグネシウム水酸化物 (Mg(OH) 2 ,ポリエチレングリコール (PEG) などが一般的に使用されます.

研究の目的:

手術で矯正されたARM患者の便秘の治療におけるSennosides,Mg (OH) 2,PEGの有効性と使用者の好みを比較する.
処理後の排泄量と排泄率を評価する
3つの異なる薬治療の間で患者の好みを評価する.

主な方法:

手術で修正されたARMと便秘の15人の患者を対象としたランダム化クロスオーバー試験です.
それぞれの患者は21日間の間隔でセノシド,Mg,OH,2およびPEGを投与された.
主要な結果:リーチスコアによる排泄量副次的な結果:清潔な排泄量とユーザー好みのスコア

主要な成果:

平均 Leech スコアは,セノシド (6. 67±2. 09),Mg (((OH)) 2 (6. 80±2. 37),およびPEG (5. 80±2. 04) (p=0. 841) と比較されました.
清潔な糞便の負荷率は,セノシドの40%,Mg (OH) 2の46. 67%,PEGの60%であった (p=0. 655).
ユーザの好みは,MgO2 (6. 33 ± 2. 94) とPEG (5. 06 ± 2.28) よりもSennosides (7. 00 ± 2.36) を好み,第三期にはMgO2の好みが減少した.

結論:

ARM患者における便秘に対するSennosides,Mg,OH,2およびPEGの有効性または使用者の好みに統計的に有意な差は認められなかった.
PEGは糞便のクリアランスを改善する傾向を示し,Sennosidesはより高いユーザー好みを示した.
微妙な違いや特定の患者のサブグループを調査するには,さらなる研究が必要かもしれません.

キーワード:

アノレクトル異常便秘クロスオーバー試験剤マグネシウム水酸化物ポリエチレングリコールセンノシド

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