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Updated: Sep 10, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

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トランジション・メタル・カタライズドC ((sp3) -H結合活性化による協調支援および急進的メカニズム:最近の進歩とメカニズム的洞察

Mohammad Sadegh Karimtabar1,2, Fatemeh Doraghi1, Bagher Larijani1

  • 1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Topics in current chemistry (Cham)
|August 26, 2025
PubMed
まとめ

活性化されていない炭素-水素結合を直接機能化することは,有機合成の鍵です. このレビューは,C ((sp3) -H結合活性化のための移行金属触媒の最近の進歩を強調し,調整支援および急進経路を強調しています.

キーワード:
エクソディレクター・グループC ((sp 3) H アクティベーション協調による機能化ネイティブ・ディレクター・グループラジカルメカニズムトレースレス・ディレクターズ・グループトランジションメタル

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Radical Reactivity: Overview01:11

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Radical reactions can occur either intermolecularly or intramolecularly. In an intermolecular radical reaction, a nucleophilic radical adds to an electrophilic alkene or vice versa. In such reactions, the radical and generally the alkene, which is also called the radical trap, are two different molecules. Additionally, for such intermolecular reactions to occur, the radical trap must be active, present in an excess concentration, and the radical starting material must have a weak...
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Radicals adjacent to electron-donating groups are called nucleophilic radicals. These radicals readily react with electrophilic alkenes. The SOMO–LUMO interactions are the driving force for the reaction, where the high-energy SOMO of the electron-rich, nucleophilic radicals interacts with the low-energy LUMO of the electron-deficient, electrophilic alkenes. Such SOMO–LUMO interactions are the basis of reactive radical traps, affecting the selectivity in radical reactions. For...
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