リン酸はミトコンドリア機能を改善し,高トリグリセリデミアにおける炎を軽減する
Nidula Mullappilly1, Sandip M Swain1, Joelle M-J Romac1
1Department of Medicine, Duke University, North Carolina, USA.
まとめ
リン酸補給は,高トリグリセリデミア関連性炎 (HTGP) に対して保護します. カルシウム不均衡とミトコンドリア機能障害を修正し,マウスの臓の炎症と損傷を軽減します.
科学分野:
- 生物化学
- 細胞生物学
- 胃腸内科
背景:
- ハイパートリグリセリデミア関連性炎 (HTGP) は急性炎の重要な原因であるが,その根本的なメカニズムは不明である.
- 低酸塩濃度である低酸塩血症は,炎患者で頻繁に観察され,代謝障害と脂質失調症に関連しています.
研究 の 目的:
- HTGPの発達におけるリン酸の状態の重要な役割を調査する.
- リン酸補給が高血糖症マウスモデルで臓損傷を軽減できるかどうかを判断する.
主な方法:
- ハイパートリグリセリデミアのAPOC3トランスジェニックマウスモデルを使用しました.
- 内カルシウム濃度,ミトコンドリア機能,ミエロペロキシダース,炎症誘発性サイトカインを含む 内損傷マーカーの評価
- リン酸補給がこれらのマーカーとケルーリン誘発性臓炎に与える影響を評価した.
主要な成果:
- ハイパートリグリセリデミアのマウスは,臓損傷,高濃度の非ER臓器カルシウム,ミトコンドリア機能障害,炎症の増加を示した.
- リン酸サプリメントはカルシウムレベルを正常化し,ミトコンドリア機能を回復し,炎症と臓損傷を軽減しました.
- リン酸補給はまた,高トリグリセリデミックな状態で低リン酸ダイエットしたマウスの臓炎の重症を軽減しました.
結論:
- リン酸は,高トリグリセリデミア中の臓の重要な保護作用をします.
- リン酸サプリメントは,カルシウムホメオスタシスとミトコンドリア機能を回復し,炎症を軽減することによってHTGPを改善します.
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