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Updated: Sep 10, 2025

Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System
10:50

Purification and Analytics of a Monoclonal Antibody from Chinese Hamster Ovary Cells Using an Automated Microbioreactor System

Published on: May 1, 2019

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インタードメインの相互作用は,単一クローン抗体における再折畳み運動と集積を調節する

Philipp Trolese1,2, Andrea Pierangelini1, Benedetta Fongaro1

  • 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova 35131, Italy.

Journal of the American Society for Mass Spectrometry
|August 26, 2025
PubMed
まとめ

抗体CH3ドメインの安定性は,ベバシズマブのような治療用タンパク質の蓄積を防ぐために重要である. ドメイン特有の展開と再折り方を理解することは,より安定した抗体治療法の設計を導く.

キーワード:
集積する水素-デウテリウム交換質量スペクトロメトリーモノクローナル抗体リフォールディング展開する

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