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Updated: Sep 10, 2025

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
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薬物の代謝物質を眼疾患の潜在的手段として二重β-アドレナゲン受容体-炭酸脱水素調節剤に再利用する

Andrea Ammara1, Alessandra Carone1, Laura Lucarini2

  • 1NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy.

Journal of medicinal chemistry
|August 26, 2025
PubMed
まとめ

研究者はミラベグロンの代謝物を化学的に改造し,二重標的の炭酸アンヒドラゼ阻害剤とベータ3アドレネルゲン受容体のアゴニストを作り出した. 眼内高血圧の治療の可能性を示唆する.

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
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