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Updated: Sep 10, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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高脂肪食による脂肪細胞におけるエストロゲン受容体のエピジェネティックプログラミングは,肥満による炎症を調節する

Rui Wu1, Fenfen Li2, Shirong Wang2

  • 1School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.

JCI insight
|August 26, 2025
PubMed
まとめ

高脂肪食は,白脂肪組織におけるエストロゲン受容体アルファ (Esr1) 遺伝子のDNAメチル化を増加させ,炎症とインスリン抵抗性を悪化させる. このメチル化が減少すると,マウスの代謝状態が改善されます.

キーワード:
脂肪組織内分泌学エピジェネティクスメタボリズム肥満

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