関連する実験動画

Updated: Sep 10, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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ピオケリン生物合成の詰まったエピメラーゼドメインは,消滅したメチルトランスファーゼである

Trey A Ronnebaum1, Kathleen M Meneely2, Geoff P Horsman3

  • 1Department of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.

Biochemistry
|August 26, 2025
PubMed
まとめ

非リボソームペプチド合成酵素 (NRPS) は通常,D-アミノ酸の組み込みのためにエピメラーゼドメインを使用する. しかし,2-ヒドロキシフェニルチアゾリン天然製品の"詰め込み"エピメラーゼドメインは,触媒的に無活性であり,非機能メチルトランスファーゼであることを示唆する.

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