関連する実験動画

Updated: Sep 10, 2025

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
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Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

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AIによる移行経路サンプリングによって捕捉されたSTIM1のトランスメブランヘリックス二分化

Ferdinand Horvath1, Hendrik Jung2, Herwig Grabmayr3

  • 1Institute of Theoretical Physics, Johannes Kepler University Linz, 4040 Linz, Austria.

Proceedings of the National Academy of Sciences of the United States of America
|August 26, 2025
PubMed
まとめ

ストロマル相互作用分子1 (STIM1) のタンパク質二酸化は,カルシウム検出の鍵です. AIによるシミュレーションでは,3つの異なるSTIM1トランスメブランヘリックスダイマー構成が明らかになり,そのメカニズムが明確になりました.

キーワード:
STIM1 についてTM・ヘリックス・ディメリゼーション貯蔵されたカルシウム入力移行経路のサンプリング

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