関連する実験動画

Updated: Sep 10, 2025

Covalent Immobilization of Proteins for the Single Molecule Force Spectroscopy
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Covalent Immobilization of Proteins for the Single Molecule Force Spectroscopy

Published on: August 20, 2018

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FUSの折りたたみRRMドメインをモデルCAPRIN1コンデンサに分割する原子解像度相互作用

Rashik Ahmed1,2,3,4, Jeffrey P Bonin1,2,3, Julie D Forman-Kay3,4

  • 1Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

Journal of the American Chemical Society
|August 26, 2025
PubMed
まとめ

この研究では,折りたたまれたFUSRNA認識モチーフ (RRM) タンパク質が,生物分子凝縮物内のCAPRIN1脚架タンパク質に結合する方法を明らかにしました. これらの相互作用は選択的クライアント濃縮を誘導し,CAPRIN1のリン酸化によって破壊される.

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