JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us
このページは機械翻訳されています。他のページは英語で表示される場合があります。 View in English

NONOは,潜在的PI3K/AKT依存メカニズムを通じてモノサイトマクロファージの系統分化を調節する.

  • 0Department of Physiology, Basic Medical School, Guangdong Medical University, Zhanjiang, China.
Differentiation; Research in Biological Diversity +

|

2025年8月26日

PubMedで要約を見る

まとめ

この要約は機械生成です。

関連する概念動画

Differentiation of Common Myeloid Progenitor Cells 01:15

3.3K

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

PI3K/mTOR/AKT Signaling Pathway 01:22

3.9K

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...

Lineage Commitment 01:21

3.1K

Commitment is the  process whereby stem cells:

 lose their ability to form all cell types and
irreversibly change into a specific type.

The multipotent hematopoietic stem cells, (HSCs), differentiate into the multipotent hematopoietic progenitor cells,  (HPCs). The HPCs express many lineage-specific cytokine receptors. Each of these receptors binds specific cytokines, activates distinct signaling pathways, and expresses a particular gene set. The HPCs further differentiate to...

Regulation of Angiogenesis and Blood Supply 01:24

2.7K

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...