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Updated: Sep 10, 2025

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
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リンバチ酸は,HPX- MAPK経路を通じてレネヴァチニブ耐性を促進する

Jinlu Han1, Chen Wang1, Yun Song1

  • 1Department of Gastroenterology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, China.

Ecotoxicology and environmental safety
|August 26, 2025
PubMed
まとめ

肝細胞がん (HCC) のレネヴァチニブ耐性を誘発する要因は,HPX遺伝子のダウンレギュレーションである. HPXの回復は,HCCの治療における薬剤耐性の克服の可能性を示しています.

キーワード:
バイオインフォマティック分析肝細胞がんレンバチニブに対する耐性MAPK信号経路ネットワーク毒性フタラート

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