関連する実験動画

Updated: Sep 10, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

431

エンジニアリングされたT細胞は,強烈な抗腫瘍免疫のために,デンドリット細胞の募集と抗原の拡散を刺激する

Zhen Xiao1, Jiajia Wang1, Shidian He2

  • 1National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China; Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China.

Cell reports. Medicine
|August 26, 2025
PubMed
まとめ

Flt3LとXCL1 (FX) を分泌するようにT細胞を設計することで, dendritic cell (DC) の活性と抗腫瘍免疫が強化されます. このアプローチはT細胞とDCの相互作用を改善し,強力な腫瘍除去につながり,固体腫瘍の免疫脱出を防ぐ.

キーワード:
CAR-Tセル抗原の拡散デンドリット細胞内生性T細胞人間化したマウスモデル免疫療法幹細胞のようなT細胞

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