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Updated: Sep 10, 2025

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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BET阻害とSMAC模倣剤を組み合わせると,腫瘍の成長を抑制し,臨床前がんモデルにおける免疫監視を誘発する

Ksenija Slavic Obradovic1, Florian Ebner1, Artem V Artemov1

  • 1Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria.

Cell reports. Medicine
|August 26, 2025
PubMed
まとめ

SMAC模倣剤 (SMACm) とBET阻害剤 (BETi) の組み合わせは,がん治療において有望であることが示されています. この薬の組み合わせは,がん細胞の増殖を効果的に減らし,腫瘍の微小環境を標的として抗腫瘍免疫を強化します.

キーワード:
BET阻害SMAC ミメティックcIAP について細胞死併用療法腫瘍の微小環境

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