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補正:N4BP3は,K63関連RIPK2ユビキチネーションを媒介することによって,炎症性腸疾患におけるNOD2-MAPK/NF-κB経路を促進する.

  • 0Department of Digestive Diseases, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, 161 Shaoshan Road, Changsha, 410000, China.
Cell Death Discovery +

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2025年8月26日

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2025年8月26日

まとめ

No abstract available on PubMed

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...