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Updated: Sep 10, 2025

Measurement of Heme Synthesis Levels in Mammalian Cells
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ユカリオット細胞におけるヘム配分は,FLVCR1b経由で細胞内GAPDHへのミトコンドリアのヘム輸出に依存する

Dhanya Thamaraparambil Jayaram1, Pranav Sivaram1, Pranjal Biswas1

  • 1Department of Inflammation and Immunity, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, Cleveland, OH, USA.

Nature communications
|August 26, 2025
PubMed
まとめ

ミトコンドリアのヘムエクスポートタンパク質FLVCR1bは,細胞性GAPDHに必須のコファクターヘムを供給し,細胞分布を可能にします. TANGO2が関与するこの経路は,細胞機能に不可欠なヘムタンパク質に到達することを保証します.

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