パルフルオオクタン硫酸に対する環境曝露と食道がんの進行におけるその役割:包括的なバイオインフォマティクスと実験的研究

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Updated: Sep 10, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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Published on: December 23, 2022

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Fangyi Liu1,2, Yansong Lin1,2, Lixuan Liu1,2

  • 1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.

Scientific reports
|August 26, 2025
PubMed
まとめ

環境に有害なパーフルオオクタン硫酸塩 (PFOS) への曝露は,PLAU,TOP2A,BAX発現を変化させ,食道がん (ESCA) を悪化させる. これらの遺伝子は,PFOSに関連したESCAのバイオマーカーおよび治療標的として機能し,環境規制の必要性を強調します.

キーワード:
食道がん免疫の浸透機械学習分子ドッキング分子動力学PFOS について毒性のターゲット

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