周周脂肪は,肝臓脂肪と共に肥満の異質性を形成する見過ごされた脂肪貯蔵庫です
Yixin Chen1, Ting Zhang2, Baoding Qin1
1Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology & Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
International journal of obesity (2005)
|August 26, 2025
まとめ
肥満におけるメタボリックシンドロームの主要な指標である. 明確な内臓脂肪のパターンは特定の代謝合併症と相関しており,リスク評価のための標的定量化を示唆しています.
科学分野:
- メタボリック・ヘルス
- 肥満に関する研究
- 心血管疾患
背景:
- 肥満は複雑な疾患で 心血管や代謝に様々な影響を及ぼします
- 肥満に関連する合併症の管理には 異なる内臓脂肪貯蔵の役割を理解することが重要です
研究 の 目的:
- 代謝的に不健康な肥満に関連する 主要な内臓脂肪を特定する.
- 特定の肥満関連の合併症に関連した脂肪の分布パターンを調査する.
主な方法:
- 319人 (BMI ≥24 kg/m2) の脂肪選択MRIの遡及分析
- 肥満,2型糖尿病 (T2DM),高血圧,脂質不全のグループに分類する.
- 肝臓,臓,前腹腔,中腹腔,外腎脂肪 (PrFT) の分布の評価
- 脂肪の蓄積と合併症を関連付けるための相関分析とロジスティック回帰分析
主要な成果:
- 周周脂肪酸 (PrFT) は血圧と強く相関しており,高血圧患者ではPrFTが最も高かった.
- 肝臓脂肪はグルコース代謝と最も関連しており,T2DM群では濃度が高い.
- 中度重度の肝硬変はメタボリックシンドロームのリスクを3. 06倍/ 6. 79倍に増加させ,PrFTの1cmの増加は2. 24倍に増加させました.
結論:
- 周周脂肪 (PrFT) と肝脂肪は代謝症候群の重要な決定因子である.
- 異なる内臓脂肪の分布パターンが異なる代謝異常を特徴づける.
- 周周脂肪および肝脂肪の定量化により,代謝症候群のリスクのプロファイリングが簡素化されます.
関連する概念動画
Cholesterol: Significance and Regulation
678
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
678
Obesity
612
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
612
Hypodermis
5.3K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
5.3K
External Anatomy of the Kidney
1.6K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
1.6K
Overview of Lipid Metabolism
2.4K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.4K


