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Updated: Sep 10, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
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模組化および地域選択的N-アルキル化によるアゾール化学空間の解鎖

Céline Dorval1, Adrian D Matthews1, Karina Targos1

  • 1Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.

Nature chemistry
|August 26, 2025
PubMed
まとめ

研究者は,様々なN-アルキルアゾール化合物を合成するための新しい方法を開発し,現在のアゾールN-アルキル化戦略の限界を克服しました. この塩基触媒による水酸化方法により,以前は作るのが困難だったアゾール構造にアクセスできます.

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