関連する実験動画

Updated: Sep 10, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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オンコメタボライト5-IP7は,イノシトール5フォスファタゼを阻害し,E-カデリン内細胞化を許可する

Hongyun Zhang1, Bobo Zhang1, Yuebo Zhao1

  • 1School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.

Nature chemical biology
|August 26, 2025
PubMed
まとめ

5 - ディフォスフィノシトールペンタキスファート (5- IP7) と呼ばれる代謝物は,結腸直腸がんにおけるE- カデリンの損失を誘導し,内細胞化を促進する. 5 - IP7を生成するIP6K2をターゲットにすることで,炎症と癌から腸内壁を保護することができます.

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