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Updated: Sep 10, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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染色体状態とATMシグナル伝達によるDNA損傷による転写ストレスの交差

Irene Salas-Armenteros1, Maarten Klunder1, Wim Vermeulen2

  • 1Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, 3015 GD, The Netherlands.

The EMBO journal
|August 26, 2025
PubMed
まとめ

DNAダメージ応答 (DDR) はクロマチンの変化を伴う. 停滞したRNAポリメラーゼIIはアセチル化,Rループ形成,ATMシグナリングを誘発し,クロマチンとDDR経路のクロス調節を明らかにする.

キーワード:
クロマチンアセチル化DNAダメージ応答シグナルRループスプライソームトランスクリプション ストレス

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