AAV遺伝子療法は,CLIC5の聴覚障害のモデルで聴覚とバランスを回復させる

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Updated: Sep 10, 2025

Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane
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Surgical Method for Virally Mediated Gene Delivery to the Mouse Inner Ear through the Round Window Membrane

Published on: March 16, 2015

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Roni Hahn1, Shahar Taiber1, Olga Shubina-Oleinik2

  • 1Department of Human Molecular Genetics & Biochemistry, Gray Faculty of Medical & Health Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 6997801, Israel.

EMBO molecular medicine
|August 26, 2025
PubMed
まとめ

アデノ関連ウイルス (AAV) を用いた遺伝子治療は,内耳疾患に対して有望である. AAVはマウスでCLIC5の発現を効果的に回復し,低用量で聴覚とバランスを維持しました.

キーワード:
AAV について聴覚障害遺伝子療法ステレオシリアベスティブル機能障害

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