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Updated: Sep 10, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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KLF11は,YAP1発現のダウンレギュレーションを通じて,M1マクロファージの極化を調節することによって,関節リウマチを緩和する

Xiaodan Liu1, Fang Fang2, Hongmei Duan2

  • 1Clinical Laboratory Department, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.

Arthritis research & therapy
|August 27, 2025
PubMed
まとめ

この研究は,KLF11がリウマチ性関節炎 (RA) でダウンレギュレーションされていることを明らかにしています. RAのモデルにおけるKLF11濃度の上昇は,M1マクロファージの極化とERK経路を阻害することによって,疾患の重症度および骨の損傷を軽減します.

キーワード:
ERK信号経路クリュッペルのような因子11マクロファージの極化リウマチ性関節炎はいに関連したタンパク質 1

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