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Updated: Sep 10, 2025

In vitro Organoid Culture of Primary Mouse Colon Tumors
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In vitro Organoid Culture of Primary Mouse Colon Tumors

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KLK1は,B1R媒介の線維細胞現象変異を抑制することによって,上皮特異的なブレーキとして結腸直腸腫瘍形成を抑制する

Lisha Zhou1, Meijing Wang2,3, Shunji Liu1

  • 1State Key Laboratory of Pharmaceutical Biotechnology and Nanjing Drum Tower Hospital, School of Life Sciences, Chemistry and Biomedicine Innovation Center, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu, 210023, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 27, 2025
PubMed
まとめ

カリクレイン-1 (KLK1) 補給は,炎症性腸疾患 (IBD) と大腸炎関連結腸癌 (CAC) に対して保護します. KLK1は腸壁の整合性と正常なストロマ機能を維持し,治療的可能性を秘めています.

キーワード:
ブラジキニンB1受容体癌に関連した線維芽細胞細胞外マトリックス腸の障壁組織カリクリーン

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In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability10:22

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Cell sorting plays an...
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