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Updated: Sep 10, 2025

Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
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腫瘍内皮細胞は,IL-4経由でM2マクロファージの極化を引き起こし,肝細胞がんにおける腫瘍の成長を促進する

Daijiro Matoba1,2, Takehiro Noda1, Shogo Kobayashi1

  • 1Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan.

Cancer science
|August 27, 2025
PubMed
まとめ

腫瘍内皮細胞 (TECs) は,IL-4分泌を介してM2マクロファージの偏分を誘導し,免疫抑制につながることで,肝細胞がん (HCC) の進行を促進します. この相互作用は,HCCの開発における重要なメカニズムを強調しています.

キーワード:
免疫抑制腫瘍の微小環境腫瘍血管腫瘍関連マクロファージ腫瘍内皮細胞

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