口腔病原菌はB2細胞を動員することで心筋梗塞を悪化させる

Bo-Yan Chen^1,2,3,4,5, Hong Zhu^1,3,4,5,6, Yu-Lin Li^3,4,5

¹Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China (B.-Y.C., H.Z., M.Y., Q.C., S.-Z.D.).

Circulation

|August 27, 2025

まとめ

歯周病は心臓に蓄積する口腔病原体によって心筋梗塞 (MI) を悪化させ,炎症性B2細胞を活性化させます. 歯周炎や口腔細菌を標的とした治療は,心臓発作の治療を改善する可能性があります.

科学分野:

心血管研究
微生物学
免疫学

背景:

心筋梗塞 (MI) は,世界中で主要な死因です.
歯周病 (PD) は心筋梗塞に関連していますが,直接的な影響とメカニズムは不明です.
MIの病原性における口腔病原体の役割は明らかにする必要があります.

研究の目的:

歯周炎が心筋梗塞に及ぼす直接的な影響を調査する.
MIの悪化に関与する口腔病原体を特定する.
微生物信号がMIの病原性を調節するメカニズムを探求する.

主な方法:

リガチュア誘発性PDとMIを組み合わせたマウスモデルが使用された.
バクテリアの配列解析とFISHで心臓の組織に経口外病原体が見つかりました
フロー・サイトメトリーとグノトビオティックマウス実験で,B2細胞の反応が特徴付けられました.
遺伝子ノックアウトマウス株と変異した細菌株が機械学的研究に使用された.
MIとPDのヒト患者は臨床的相関性のために採用されました.

主要な成果:

歯周病と口腔病原菌はマウスモデルでMIを悪化させた.
*Prevotella intermedia* と *Fusobacterium nucleatum* を含む特定の口腔病原菌が特定されました.
これらの病原生物は心臓発作の心臓に蓄積され皮質と内皮質の障壁を損なった.
経口の病原菌は炎症を誘発するB2細胞を動員し,心臓発作の重症度を高めました
心臓へのB細胞移動は,S1P-S1PRとCXCL13-CXCR5信号伝達経路によって媒介された.

結論:

口腔の病原菌とB2細胞は MIを著しく悪化させ,新しい口腔-心臓軸を確立します.
PD,口腔病原体,または関連する免疫メカニズムを標的とした介入は,MIの治療の可能性を示しています.

キーワード:

Bリンパ球のサブセット心筋梗塞歯周病

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