関連する実験動画

Updated: May 7, 2026

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
08:41

Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages

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IL - 18 テトラペプチド配列に基づくカスパース−8の強力な阻害剤は,炎症およびアポプトシスイニシアターカスパースの共通の特異性を明らかにする

Christopher M Bourne1, Nicole R Raniszewski1, Ashutosh B Mahale1

  • 1Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.

ACS bio & med chem Au
|August 27, 2025
PubMed
まとめ

研究者は,炎症と細胞死における重要な酵素であるカスパース8を標的とした新しいペプチド阻害剤を開発しました. このLESDベースの阻害剤は,既存の選択肢よりも強力で,カスパスを研究するための改善されたツールを提供します.

キーワード:
イエルシニア・プスドートゥベルキュロスアポトーシスカスパース阻害剤カスパース基板インビトロ運動インフラマソームピロプトーシス

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The Extrinsic Apoptotic Pathway

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