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Updated: Sep 10, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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5'-フォスフォロチオエステル連結サイクリック・ディヌクレオチド,Endo-S-CDNは,皮下投与時にインビョで印象的な抗腫瘍活性を示している

Simpa K Yeboah1, Sagarika Meher2, Haley Anne Harper3

  • 1James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.

ACS bio & med chem Au
|August 27, 2025
PubMed
まとめ

強力なSTINGアゴニストである新型エンド-S-CDNは,がん免疫療法の有効な皮下投与を示しています. これらの周期性ダイヌクレオチドは,挑戦的な腫瘍モデルに対して強力な保護を提供し,腫瘍内投与制限を改善します.

キーワード:
5′-リン酸化エステル結合PDE 安定したスティング癌についてサイクル・ディヌクレオチド・アナログ免疫療法

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