関連する実験動画

Updated: Sep 10, 2025

TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing
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TGF-β-mediated Endothelial to Mesenchymal Transition EndMT and the Functional Assessment of EndMT Effectors using CRISPR/Cas9 Gene Editing

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ATF6とSNAI1の間の自己増幅ループをターゲットにすることで,線維性病変における上皮質−メゼンキマ移行を阻害する

Tong Wu1, Yan Liu1, Jiyuan Ma1,2

  • 1Department of Ophthalmology, Xijing Hospital, Eye Institute of Chinese PLA, Fourth Military Medical University, 710032 Xi'an, China.

Theranostics
|August 27, 2025
PubMed
まとめ

転写因子6 (ATF6) とスナイルファミリー転写抑制剤1 (SNAI1) を活性化する新しい自己増強フィードバックループは,未展開のタンパク質応答依存性上皮質-メゼンキマトランジション (EMT) を誘発する. メラトニンはこのATF6-SNAI1ループを効果的に阻害し,繊維性疾患の治療戦略を提供します.

キーワード:
活性化トランスクリプション因子6白内障エピテリア・メゼンキマ移行メラトニンスナイルファミリーの転写因子

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