関連する実験動画

Updated: Sep 10, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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TSG6は,TSG6-CD44-TGFβR1またはEGFR複合体の形成を促進することによって,Smad2/3およびMAPKシグナル伝達を通じて,上皮質-メセンキマの移行および腫瘍関連マクロファージの極化を促進する

Hyun-Ji Oh1, Ga-Hong Min1, Da-Eun Kim1

  • 1Department of Pharmacy, College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi-do 15588, Republic of Korea.

International journal of biological sciences
|August 27, 2025
PubMed
まとめ

腫瘍死滅因子アルファ刺激遺伝子/タンパク質6 (TSG6) は,上皮-メゼンキマ移行 (EMT) を強化し,免疫細胞を再プログラムすることによって,肺がんの進行を促進します. TSG6をターゲットにすることで,肺腺がん (LUAD) の治療戦略が提供される可能性があります.

キーワード:
CD44 についてTSG6 について侵入性について腫瘍関連マクロファージ

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