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Updated: Sep 10, 2025

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
07:18

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening

Published on: May 12, 2017

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PLK4は神経芽細胞瘤の差別化の重要な調節体であり,有望な治療標的である

Xiangdong Tian1, Yuren Xia1, Wenchen Gong1

  • 1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Tianjin, China.

International journal of biological sciences
|August 27, 2025
PubMed
まとめ

PLK4は神経芽細胞瘤の分化を調節し,これは予後における重要な要因である. PLK4を阻害すると,ニューロンの成熟が促進され,13- cis RA治療に対する抵抗が克服される可能性があります.

キーワード:
CXCR4 についてPLK4 についてサイクリンD1差別化療法神経芽細胞腫

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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

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