ディスタル半径骨折の患者における複雑な地域疼痛症候群におけるビタミンC
Fernando Antonio Silva de Azevedo Filho1,2, Roberta Muniz Blunck1, Abdouni Y Ali3
1Hospital do Subúrbio, Salvador, Bahia, Brazil.
Revista brasileira de ortopedia
|August 27, 2025
まとめ
ビタミンCサプリメントは,遠半径骨折の手術を受けた患者の複雑な地域疼痛症候群 (CRPS) と神経病痛の発生率を著しく減少させた. 手術後の痛みのコントロールも改善した.
科学分野:
- 整形外科
- 痛みの管理
- 栄養学
背景:
- 複雑な地域疼痛症候群 (CRPS) は,骨折後に発生する衰弱状態です.
- 半径の遠端骨折 (FDER) は一般的であり,大きな痛みや障害を引き起こす可能性があります.
- CRPSの予防と術後の痛みの管理における栄養介入の役割は,現在進行中の研究分野です.
研究 の 目的:
- 半径骨折の遠端に手術を受けた後のCRPSの予防におけるビタミンCの有効性を調査する.
- 神経病痛の発生と重症度に対するビタミンCの影響を評価する.
- 手術後の痛みに対するビタミンCの効果を評価する.
主な方法:
- 手術が必要なFDERの成人の患者を対象にランダム化制御試験が行われました.
- 参加者は手術後60日間,毎日1gのビタミンCまたはプラセボを与えられました.
- 測定されたアウトカムには,CRPSの発生率,神経疾患の痛み (VASを用いて),様々な時間点での痛みのスコアが含まれていた.
主要な成果:
- プラセボ群と比較して,ビタミンC群では神経疾患の発症率が著しく低かった (p=0. 008).
- ビタミンCを投与された患者は,平均的な視覚アナログスケール (VAS) の痛みのスコアが低いことを報告した (p=0. 001).
- 12週と24週でCRPSの発生率は,ビタミンCの介入群で統計的に低い (p=0. 014とp=0. 007).
結論:
- ビタミンCは,遠半径骨折後の複雑な地域疼痛症候群 (CRPS) の予防に有意な効果を示しています.
- ビタミンCのサプリメントは神経疾患の発生率を低減し,手術後の痛み管理を改善する効果があります.
- この研究は,FDER患者の疼痛緩和およびCRPS予防のための補助療法としてビタミンCの使用を支持しています.
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