関連する実験動画

Updated: Sep 10, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

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希少変異分析における勝利者の呪い:効果の大きさの推定バイアスは,効果の方向と使用された関連方法に依存する

David Soave1,2, Melisa Hayalioglu1, Lei Sun3,4

  • 1Department of Mathematics, Wilfrid Laurier University, Waterloo, ON, Canada.

Frontiers in genetics
|August 27, 2025
PubMed
まとめ

複合的な特徴に対する希少変異 (RV) の影響を推定することは,バイアスのために困難です. この研究は,勝者の呪いと変異異性の異質性が,平均遺伝効果 (AGE) の推定で競争する上下バイアスをどのように生み出すかを示しています.

キーワード:
効果の異質性評価する全ゲノム関連研究共同分析珍しい変種選択バイアス勝利者の呪い

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