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Updated: Sep 10, 2025

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice
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Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice

Published on: September 16, 2020

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骨折誘発免疫カスケード 骨細胞調節による急速な全身性骨喪失

Lipeng Sun1, Shouxiang Kuang1, Yang Li1

  • 1Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People's Republic of China.

ImmunoTargets and therapy
|August 27, 2025
PubMed
まとめ

骨細胞のSTAT3依存RANKL経路を通じて骨格細胞の活性を増やすことにより,骨折後の骨の損失を悪化させる. このIL-6/STAT3/RANKL軸をターゲットにすることで,さらなる骨折を防ぐことができる.

キーワード:
RANKL について骨折 の 治癒骨折のリスク炎症オステオサイト骨粗鬆症

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