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Updated: Sep 10, 2025

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Accessing the Cytotoxicity and Cell Response to Biomaterials
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カルシウムシリケートベースの歯科用バイオマテリアルの水分化に対する灌溶液の影響:in vitro研究
Pradeep M Divya1, Amit Jena1, Saumyakanta Mohanty1
1Department of Conservative Dentistry and Endodontics, Srirama Chandra Bhanja Dental College and Hospital, Cuttack, Odisha, India.
Journal of conservative dentistry and endodontics
|August 27, 2025
まとめ
チトサンベースの内放射性不透明溶液 (CERS) とトリカルシウムシリケートシーラーからの塩素強化カルシウムイオン放出. 塩化ナトリウムとエチドロン酸の溶液は,この放出を減少させ,シーラー生物活性に影響を与えた.
科学分野:
- エンドドンティクス
- バイオマテリアル科学
- 歯科用 材料
背景:
- カルシウムシリケートベースの根管シール剤は,その生物互換性および生物活性で知られています.
- シーラー特性に対する灌溶液の影響を理解することは,エンドドント治療の成功に不可欠です.
研究 の 目的:
- トリカルシウムシリケートベースの根管密封剤の水分化特性とカルシウムイオン放出に対する様々な灌溶液の影響を評価し,比較する.
- 異なる灌剤による生物活性調節を評価する.
主な方法:
- 2つのトリカルシウムシリケートシーラー:Dia-Root Bio SealerとCeraSealを用いたインビトロ試験
- シーラーサンプルを4つの灌溶液に浸した. 3%のナトリウム低塩化物 (NaOCl),エディトロニック酸 (EA),キトーサンベースの内放射性不透明溶液 (CERS),および通常の塩水.
- 分析には,エネルギー分散光譜によるスキャニング電子顕微鏡,フーリエ変換赤外線光譜,およびカルシウムイオン放出のための誘導結合プラズマが含まれていた.
主要な成果:
- 灌溶液は水分化特性とシールアイオンの放出に大きく影響した.
- CERSと通常の塩水に浸されたサンプルでは,NaOClまたはNaOCl + EAで処理されたものと比べて,著しく高いカルシウムイオン放出を示した (P < 0.001).
- CeraSealはDia- Root Bio Sealerよりも高いカルシウムイオン浸出性を示しました.
結論:
- CERSは,カルシウムイオン放出を増やすことで,トリカルシウムシリケートベースのシール剤の生物活性に好影響を与える.
- 灌溶液の選択は,バイオセラミック根管シール剤の水分と生物活性に重大な影響を及ぼします.
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