サルコペニ性肥満に対する食事による炎症の可能性の高まりの影響: 2つの観察研究からの証拠

Xi Luo¹, Weiwei Jin¹, Shengcheng Mao²

¹Department of Clinical Nutrition, Tongde Hospital of Zhejiang Province, Hangzhou, China.

Frontiers in nutrition

|August 27, 2025

まとめ

食事による炎症指数 (DII) の高いスコアは,サルコペニ性肥満 (SO) のリスクの増加と関連しています. この関連性は部分的に炎症および栄養的要因によって説明され,DIIを潜在的なリスク指標として強調しています.

科学分野:

栄養学
ゲロントロジー
炎症に関する研究

背景:

慢性的な低度の炎症はサルコペニアと肥満に関わっている.
ダイエットは炎症とこれらの状態に影響を与える重要な変化可能な要因です

研究の目的:

ダイエット炎症指数 (DII) で測定される食事による炎症の可能性とサルコペニック肥満 (SO) の関連性を調査する.

主な方法:

NHANES (2015年−2018年) からの4,470人の被験者と,中国のコホートからの276人の分析.
DII-SO関係を評価するためのロジスティック回帰.
CALLYとNPARを用いたNHANESコホートにおけるメディエーション分析

主要な成果:

NHANES (aOR=1. 19) と中国のコホート (aOR=1.59) の両方で,より高いDIIスコアとSOとの間で正の関連性が見られた.
CALLYは39. 49%,NPARはNHANESコホートにおけるDII- SO結合の7. 35%を媒介した.

結論:

DIIの値が上昇すると,成人のSOリスクが増加します.
炎症/栄養経路は部分的にこの関連を媒介する.
DIIはSOのリスクのある個人を特定するのに有用な指標です.

キーワード:

CRP アルブミンリンパ球指数 NHANES について食事による炎症指数中性粒子の割合とアルブミン比サルコペニック肥満

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