周液採集の内視経口排水に対する酸抑制薬の作用 - ランダム化制御試験
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まとめ
この要約は機械生成です。アシド抑制薬は 臓のキスト液の微生物を変化させ 術後の炎症マーカーを増加させます これは,内視の排水手順の後に感染のリスクが増加する可能性を示唆しています.
科学分野
- 胃腸内科
- 微生物学
- 手術腫瘍学
背景
- 胃酸抑制薬は胃酸の分泌を減らすことで腸内微生物群に影響します.
- これらの薬剤が周流出の微生物およびその後の術後の合併症に及ぼす影響は不明である.
研究 の 目的
- 胞液内の微生物群に対する酸抑制薬の影響を調査する.
- 臓キスタの手術を受ける患者の術後の合併症に対する酸抑制の影響を評価する.
主な方法
- 予期的なランダム化比較試験は45人の患者で実施された.
- 患者は2つのグループに分けられ,酸抑制剤を投与された患者と投与されなかった患者でした.
- 主なエンドポイントは,小胞液の微生物群の差異の分析でした.
主要な成果
- 術後感染,出血,再発率の有意な差異は観察されなかった.
- アシド抑制群は,手術後のC反応性タンパク質濃度が大幅に上昇し,炎症が増加したことを示した.
- 微生物群のアルファ多様性は違わなかったが,ベータ多様性は統計的に有意な違いを示した.
結論
- 酸抑制薬は 臓の微生物の組成を変えます
- これらの薬は,手術後の炎症マーカーの増加と関連しています.
- アシド抑制療法では,内視排水後の感染のリスクが上昇する可能性があります.
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