MAFLD: 代謝機能障害と心血管リスクの関連性に関する包括的なレビュー

Alaa M Mostafa¹, Ziyan Pan², Ming-Lung Yu^3,4

¹Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, Minia, Egypt.

Hepatic medicine : evidence and research

|August 27, 2025

まとめ

代謝機能障害に関連した脂肪肝 (MAFLD) は,世界的に30%以上で,心血管疾患 (CVD) のリスクを大幅に増加させる. 早期発見と生活様式の変化は,MAFLD を管理するに大切なものです

科学分野:

肝臓病と心臓病
メタボリックシンドロームの研究

背景:

代謝機能障害に関連した脂肪肝 (MAFLD) は,世界人口の30%以上に影響します.
MAFLDは心臓血管疾患 (CVD) と強く関連している多システム疾患で,死亡の主な原因です.

研究の目的:

MAFLDと心血管疾患 (CVD) を関連付ける共通の病原性メカニズムを解明する.
MAFLD患者の早期発見とリスクの階層化の重要性を強調する.
MAFLDの心臓血管への影響に関する現在のおよび将来の管理戦略をレビューする.

主な方法:

MAFLDの病理生理学とCVDとの関連に関する既存の文献のレビュー.
インスリン抵抗性,炎症,酸化ストレス,遺伝学を含む共有メカニズムの分析.
診断ツール (非侵襲的イメージング,バイオマーカー) と治療方法の検討

主要な成果:

主な共通メカニズム (インスリン抵抗性,炎症,酸化ストレス,遺伝) は,MAFLDと冠動脈疾患,心筋不全,心不全のリスクを関連付けています.
非侵襲的な方法による早期発見はリスクの階層化に不可欠です

結論:

MAFLDは,相互に関連した代謝経路と炎症経路を通じて,心血管疾患のリスクを大幅に高めます.
ライフスタイルの変更と標的型薬物療法を組み合わせた個別化された介入は不可欠です
MAFLDの心血管合併症の管理には多学科的なアプローチが不可欠です.

キーワード:

心臓代謝リスク脂肪肝代謝機能障害薬剤療法

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