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Updated: Sep 10, 2025

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

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臓腺がん患者のトランスクリプトミックの分析は,KRAS媒介によるPPAR経路の変化を明らかにした

Giuseppe Defazio1, Federico Scolari1, Sara Fancelli2

  • 1Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.

Frontiers in oncology
|August 27, 2025
PubMed
まとめ

臓がん (PC) の生存率は低下しており,その一部はKRAS変異による. この研究では,KRAS変異PCにおけるペロキシソーム増殖器活性化受容体 (PPAR) 経路の障害が発見され,新たな治療標的が示唆された.

キーワード:
KRAS変異PPARシグナリング経路脂質代謝分子プロファイリング臓がんトランスクリプトミック分析

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